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Tomorrow's health is... Defining a new possible.

Sr. Manager, Central Fill Operations

Plano, Texas Job ID JR0152760 Category Field Operations, Distribution Operations Post Date Aug. 26, 2026
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McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

Job Summary

At McKesson, we’re all about delivering better health — making sure patients get the medications they need, safely and on time. As Sr. Manager, Pharmacy Distribution Operations, you’ll manage the day-to-day operations of one of our high-volume, automated pharmaceutical distribution centers within the Central Fill Pharmacy network. This is a customer co-located role — you’ll be based on-site with our customer as the face of McKesson, owning the day-to-day relationship and serving as their trusted operational partner.

You’ll direct supervisors, leads, and individual contributors to deliver excellence in safety, quality, service, and cost, applying operational policies to establish and achieve department goals. You’ll also partner directly with the customer to set strategy and align our operations to achieve their goals — helping shape a culture of continuous improvement, team engagement, and patient-first thinking while running daily operations, streamlining workflows, and collaborating across cross-functional teams to help us deliver on our mission.

What You’ll Do

  • Own the Customer Relationship: Serve as the primary, on-site point of contact for our co-located customer — building trust, managing the day-to-day relationship, and representing McKesson as a dependable operational partner.

  • Partner on Strategy & Customer Goals: Partner with the customer to set strategy and align our operations, priorities, and improvement initiatives to achieve their goals and deliver measurable value.

  • Lead Daily Operations: Manage daily production, resource planning, and prioritization to meet and exceed the site’s distribution goals.

  • Track Performance: Keep a close eye on KPIs like Cost per Script, Scripts per Hour, Safety Index, and employee engagement — and use them to drive results.

  • Ensure Safety & Accuracy: Make sure everything we dispense is secure, accurate, and compliant with FDA, DEA, OSHA, and Board of Pharmacy regulations.

  • Partner on Regulatory & Licensing Audits: Partner with the customer to prepare for and support audits and inspections by various regulatory and licensing agencies, keeping the site audit-ready at all times.

  • Drive Improvement: Lead initiatives to improve engineering processes, customer support, cost structure, and overall quality; build business cases to support investments and upgrades.

  • Develop the Team: Attract and develop talent at all levels; provide feedback, development plans, and coaching, and be a role model for McKesson’s ICARE and ILEAD values.

  • Manage Reporting: Create and share performance reports and analytics with customers on a regular basis, and communicate clearly across all levels to keep everyone aligned.

  • Oversee Vendors & Budgets: Manage vendor relationships, purchase orders, and expenses to stay on budget and deliver value.

  • Lead Training & Compliance: Build and maintain training programs that meet McKesson’s standards and keep the site audit-ready.

  • Support Systems & Staffing: Support pharmacy system installs and troubleshoot tech issues with internal teams and vendors; use labor modeling to forecast needs and plan staffing for volume shifts.

What You Bring

  • Education: Four-year degree in business, supply chain, operations, or a related field, or equivalent experience.

  • Central Fill and/or Pharmacy Operations and Inventory Management experience.

  • Pharmacy Technician License: A licensed Pharmacy Technician, or the ability to become a certified pharmacy technician — McKesson offers educational classes to support you in earning and maintaining certification.

  • Customer Relationship Management: Proven ability to own a customer relationship in a co-located or on-site setting, partnering on strategy and aligning operations to achieve customer goals.

  • Regulatory Audit Partnership: Ability to partner with a customer to prepare for and support audits by various regulatory and licensing agencies.

  • Experience: 9+ years of professional operations experience and 1+ years of supervisory and/or management experience; experience leading distribution or pharmacy fulfillment operations with a focus on safety, quality, and service (pharmaceutical distribution and automation preferred).

  • Financial Acumen: Solid financial skills — budgeting, forecasting, and building ROI-driven business cases.

  • Regulatory Knowledge: Working knowledge of FDA, DEA, OSHA, and Board of Pharmacy regulations.

  • Analytical Skills: Strong analytical skills and comfort with tools like Excel, Access, PowerPoint, and Warehouse Management Systems (WMS).

  • Communication & Collaboration: Excellent communication and collaboration skills — able to influence and align teams and manage external customer reporting and relationships.

  • Mindset: A customer-first mindset and a passion for developing inclusive, high-performing teams.

#LI-JT2

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

Our Base Pay Range for this position

$89,800 - $149,600

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.


McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!

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McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

  • McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.
  • McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.
  • McKesson job postings are posted on our career site: careers.mckesson.com

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