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Tomorrow's health is... Defining a new possible.

Lead Product Portfolio Manager (Oncology Clinical Research Products)

Irving, Texas, Alpharetta, Georgia, Columbus, Ohio Job ID JR0140821 Category Product Management, Information Technology Post Date Jan. 12, 2026
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McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

Current Need:

The Lead Product Portfolio Manager forGenospaceis a senior, highly specialized product leader responsible for the end-to-end portfolio strategy, product direction, and lifecycle execution ofGenospace’soncology data and clinical research solutions. This role serves as the primary product authority forGenospace’splatform and services, bridging deep clinical and data-scienceexpertisewith enterprise-scale product strategy, delivery, and governance.

This positionoperateswith broad autonomy and consultative direction, leading complex, cross-functional initiatives that span product management, engineering, data science, quality/compliance, operations, and external partners. The role is recognized internally as an in-house expert in oncology data workflows, clinical research technology, and real-world data curation.

A corecomponentof this role includes strategic product leadership across the oncology and multispecialty ecosystem, ensuringGenospaceproducts and services enable clinical research, precision medicine, and real-world data workflows across community providers, research networks, and biopharma partners. This role balances the needs of diverse stakeholders while ensuringGenospacesolutionsremainscalable, compliant, and aligned to broader enterpriseobjectives.

In addition to portfolio ownership, this role provides day-to-day functional leadership and mentorship for product managers and product ownersoperatingwithin an agile development environment, ensuring consistent product practices, high-quality decision-making, and alignment toGenospace’sportfolio strategy.

This is an individualcontributorProduct Manager role. Over time, and based on business needs anddemonstratedimpact, the scope may expand to includepeople leadershipwith direct management responsibility forGenospaceproduct team.

About Insights & Technology:

Insights & Technology is the technology, data, and insights organization powering McKesson’s Oncology and Multispecialty segment. We deliver innovative solutions that connect community providers and biopharma to improve health outcomes. Our mission is to accelerate drug development, expand patient access, and enhance care delivery—ultimately transforming the fight against cancer. By joining Insights & Technology, you’ll be part of a dynamic team at the forefront of oncology innovation, working together to make a meaningful impact for patients and providers.

This position is part of the Insights & Technology organizationand serves as a senior product leader responsible for theGenospaceproduct portfolio, providing research-quality, enterprise-ready solutions in support of oncology and multispecialty clinical research.Genospace builds data and technology solutions that support oncology clinical research, precision medicine, and real-world data applications. Our platform enables capabilities such as EHR-to-EDC data transfer, clinical trial matching, and analytics that connect sites, sponsors, and research networks.As the strategic product owner for these capabilities, this role ensuresGenospace’splatform effectively supports clinical research programs, biopharma collaborations, and partner workflows—whileremainingscalable, compliant, and aligned to broader enterprise objectives.

Key Responsibilities:

Portfolio & Product Strategy

  • Own theGenospaceproduct portfolio strategy, including platform capabilities, services,roadmap alignment,andend-to-end product success fromlaunchthrough adoptionacrossclinical research, real-world data, and precision medicine use cases.

  • Define and evolve multi-year product vision and investment strategy, balancing innovation, scalability, compliance, and commercial outcomesthroughestablishingclear KPIs to measure product performance, adoption, and impact.

  • Identifynew growth opportunities by analyzing market trends, sponsor needs, site workflows, regulatory requirements,competitive landscape, and usage patterns.

  • Lead business case development for new products, major enhancements, and portfolio optimization initiatives, including expected value realization and success metrics.

  • Develop and present portfolio-level recommendationsand performance insightsto senior business leaders to informinvestment,prioritization, and course-correctiondecisions.

Domain & Technical Leadership

  • Serve as the product authority on oncology data models, EMR-to-EDC integrations,clinicaltrial workflows, biomarker data, and real-worldevidenceuse cases.

  • Translate complex clinical, informatics, and data-science concepts into actionable product requirements and scalable solutions.

  • Guide decisions related to data curation, metadata standards, interoperability, andanalyticsreadiness.

  • Act as a trusted partnertoengineering and data science on system design, tradeoffs, and long-term architectural considerations.

Cross-Functional & Enterprise Leadership

  • Collaborate closely with engineering, data science, quality/compliance, legal, finance, sales, account management, and corporate strategy.

  • RepresentGenospaceproduct strategy in executive, governance, and partner forumsacrossMcKesson,Ontada,SCRI,and external stakeholders.

  • Provide functional leadership to product managers and product owners embedded in agile delivery teams, ensuring clarity of product vision, prioritization, and execution.

  • Lead roadmap execution and adoptionacross matrixed teams and external partners to drive alignment and execution.

  • Support commercial and partner engagements by articulating product value, differentiation, and roadmap direction.

  • Serve as an escalation point for complex product decisionsimpactingmultiple teams, products, or stakeholders, including external research partners.

Quality, Compliance & Risk-Based Thinking

  • Ensure product strategy and execution align withGxP, 21 CFR Part 11, and validated system expectations.

  • Partner with quality and compliance teams to define risk-based approaches to product changes, audit readiness, and operational controls.

  • Balance innovation with regulatory rigor in a highly scrutinized clinical and healthcare environment.

Execution & Delivery Oversight

  • Lead complex, high-impact initiatives from concept through delivery, including platform enhancements, new services, and cross-portfolio integrations.

  • Establish clear success metrics and continuously evaluate product performance, adoption, and outcomes.

  • Drive prioritization decisions thatoptimizevalue delivery while managing technical and operational constraints.

Leadership & Talent Development

  • Act as a mentor and senior leader to product managers and cross-functional partners.

  • Support onboarding, development, and performance feedback for product talent in partnership with people managers.

  • Contribute to the evolution ofGenospace’sproduct operating model, standards, and best practices.

Minimum Requirement:

  • Degree or equivalent and typically requires 10+ years of relevant experience. Less years required if has relevant Master’s or Doctorate qualifications.

Critical Skills:

  • 10+ years of progressive experience in product management, product portfolio management, or related leadership roles, preferably in healthcare, life sciences, or regulated technology environments.

  • Demonstrated experience leading complex, enterprise-scaleproductsor platforms.

  • Deep understanding of healthcare data, clinical workflows, and/or clinical research technology.

  • Proven ability to influence senior stakeholders and drive outcomes in a matrixed organization.

  • Ability to travel up to 15% of the time nationwide.

Preferred Experience

  • Background in biomedical informatics, data science, or advanced analytics.

  • Experience with oncology data, clinical trials, EMR/EHR systems, real-world evidence, or biomarker data.

  • Familiarity withGxP-regulated software development and validation frameworks.

  • Track recordof serving as a subject-matter expert within an organization.

  • Experience building or evolving product organizations and mentoring future leaders.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

Our Base Pay Range for this position

$146,600 - $244,400

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.


McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

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McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

  • McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.
  • McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.
  • McKesson job postings are posted on our career site: careers.mckesson.com.

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